I find this futuristic YouTube video is very stimulating. Dr. David Sinclair is Professor at Paul Genn Center for Biology of Aging at Harvard University researching NAD boosters such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) and their connection to longevity. BUT!
personally think we may wait years for the pill payoff! We have the same biology and biochemistry available right now to prolong our lives! And using the same concepts naturally!
Reference to Sirtuins proteins acting as environmental stress sensors. And responsible for longevity large part. This is HORMESIS. All confirm: we should use fasting and partial fasting techniques NOW! His book “Lifespan: Why We Age — and Why We Don’t Have To,” tending to future and rather mind-boggling.
Listen to his YouTube video above.
He reiterates almost casually what I see as Dr. Valter Longo’s given concepts.
Because of differences in research Longo specifically looked at time intervals. So I think Sinclair anabolic and catabolic solution is to avoid full seven days of fasting!
Crunch time at 3 days with real fat burning. Autophagy and destruction of Stem cells really start.
Second crunch time is optimal cessation at five days and not seven. Reason for Sinclair’s muscle wasting concerns!?
The refeeding stage key after Five Days and no more! It confirms my personal experience.
The number of times a year…I believe is four to be optimal but the start-up activation of the process is every month for the first three months!
It’s important after 35 and vital at 70 plus! Then keep the momentum that now leads to longevity. Aways care for medical advice and caveats depending on medical status elsewhere on this blog!
Discipline comes naturally with the process. Your body already accepts fasting.
What is really revolutionary for Sinclair:
“is the discovery of the biochemical pathways that underlie this protection against disease and ageing.”
Fasting Intermittent and Full Water our bodies respond well to this carefully thought out adversity! Hormesis!
Also, like Sinclair view on proteins. No drifting into an Atkins type diet! Care on both total quantity and type of protein is vital.
Also compensation with good fats such as olive oil, coconut oil avocado oil and avoidance of the vegetable fats ie. canola oil!
To quote Sinclair:
It’s thought that a little bit of heat, a little bit of cold, a little bit of hunger, some exercise, some hypoxia, lack of oxygen in your body..
these are all ways of activating these defence pathways …
such as sirtuins. the mTOR, which lower amino acids, particularly leucine and arginine. and the AMPK pathway.
these are the main three defensive pathways.
Sinclair’s ultimate goal to identify ways to reprogram all cells in the body.
“In my career, I’ve seen a lot of cool stuff. I haven’t seen anything this cool before,” he says.
Clearly, there’s potential for extension of the human life span beyond the current perceived limit of 120 years. Sinclair and Mercola on board. Longo already for a long while on the actual time periods!
We all should be! David Sinclair: Achieve Longevity, Assault Aging!